Photochemical Chemoselective Alkylation of Tryptophan-Containing Peptides
نویسندگان
چکیده
We report a photochemical method for the chemoselective radical functionalization of tryptophan (Trp)-containing peptides. The exploits photoactivity an electron donor-acceptor complex generated between unit and pyridinium salts. Irradiation with weak light (390 nm) generates intermediates right next to targeted Trp amino acid, facilitating proximity-driven functionalization. This protocol exhibits high chemoselectivity residues over other acids tolerates biocompatible conditions.
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ژورنال
عنوان ژورنال: Organic Letters
سال: 2021
ISSN: ['1523-7060', '1523-7052']
DOI: https://doi.org/10.1021/acs.orglett.0c03735